Giampaolo Letta joined Medusa in 1999: in 2001 he became Vice President and in November 2002 also Chief Executive Officer.
Under his leadership the company distributed The Lord of the Rings Trilogy, many movies by Woody Allen (as Match Point, Midnight in Paris and the coproduction To Rome with Love) ), Italian and US films by Gabriele Muccino (as The Pursuit of Happiness); produced and distributed some movies of the Oscar-awarded director Giuseppe Tornatore (The Unknown Woman and Baaria and before The Legend of 1900 and Malèna). He distributed many Italian blockbusters in the last ten years such as all the films with Checco Zalone, the phenomenon in the history of the Italian box office, almost all the movies by the Oscar-awarded director Paolo Sorrentino as This must be the place, The Great Beauty and Youth, all the movies by Paolo Genovese as the successful Perfect Strangers which was highly awarded all over the world, all the movies by and with Ficarra & Picone as the Christmas blockbuster Once Upon a Time in Bethlehem, all the movies by the comic trio Aldo, Giovanni e Giacomo as the last film I Hate Summer